Food Deprivation Affects the miRNome in the Lactating Goat Mammary Gland.

ABSTRACT:

Background

Nutrition affects milk composition thus influencing its nutritional properties. Nutrition also modifies the expression of mammary genes, whose regulation is not fully understood. MicroRNAs (miRNA) are small non coding RNA which are important post-transcriptional regulators of gene expression by targeting messenger RNAs. Our goal was to characterize miRNA whose expression is regulated by nutrition in the lactating goat mammary gland, which may provide clues to deciphering regulations of the biosynthesis and secretion of milk components.

Methodology/principal findings

Using high-throughput sequencing technology, miRNomes of the lactating mammary gland were established from lactating goats fed ad libitum or deprived of food for 48 h affecting milk production and comp

SUBMITTER: Mobuchon L 

PROVIDER: S-EPMC4608672 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature