The traditional Chinese herbal formula ASHMI inhibits allergic lung inflammation in antigen-sensitized and antigen-challenged aged mice.

ABSTRACT:

Background

Although asthma is typically characterized as a childhood disease, it can develop later in life. Older asthmatic patients may be at increased risk for corticosteroid adverse effects. We developed a novel traditional Chinese medicine to treat asthma called antiasthma simplified herbal medicine intervention (ASHMI). Herbal products may offer safer adjunctive treatment for older asthmatic patients.

Objective

To investigate the effects of ASHMI on characteristics of allergic asthma in an aged mouse model of asthma.

Methods

BALB/c mice (6 weeks old [young] and 6, 12, and 18 months old [aged]) received ASHMI treatment before and during intraperitoneal ovalbumin sensitization and intratracheal challenges. The control groups were untreated, age-matched, ovalbumin-s

SUBMITTER: Busse PJ 

PROVIDER: S-EPMC4608683 | biostudies-literature | 2010 Mar

REPOSITORIES: biostudies-literature