Relationship between Brain Age-Related Reduction in Gray Matter and Educational Attainment.

ABSTRACT: Inter-subject variability in age-related brain changes may relate to educational attainment, as suggested by cognitive reserve theories. This voxel-based morphometry study investigated the impact of very low educational level on the relationship between regional gray matter (rGM) volumes and age in healthy elders. Magnetic resonance imaging data were acquired in elders with low educational attainment (less than 4 years) (n = 122) and high educational level (n = 66), pulling together individuals examined using either of three MRI scanners/acquisition protocols. Voxelwise group comparisons showed no rGM differences (p<0.05, family-wise error corrected for multiple comparisons). When within-group voxelwise patterns of linear correlation were compared between high and low education groups, the

SUBMITTER: Rzezak P 

PROVIDER: S-EPMC4608774 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature