Differences in the Early Development of Human and Mouse Embryonic Stem Cells.

ABSTRACT: We performed a systematic analysis of gene expression features in early (10-21 days) development of human vs mouse embryonic cells (hESCs vs mESCs). Many development features were found to be conserved, and a majority of differentially regulated genes have similar expression change in both organisms. The similarity is especially evident, when gene expression profiles are clustered together and properties of clustered groups of genes are compared. First 10 days of mESC development match the features of hESC development within 21 days, in accordance with the differences in population doubling time in human and mouse ESCs. At the same time, several important differences are seen. There is a clear difference in initial expression change of transcription factors and stimulus responsive genes, w

SUBMITTER: Gabdoulline R 

PROVIDER: S-EPMC4608779 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature