Network-based analysis identifies epigenetic biomarkers of esophageal squamous cell carcinoma progression.

ABSTRACT:

Motivation

A rapid progression of esophageal squamous cell carcinoma (ESCC) causes a high mortality rate because of the propensity for metastasis driven by genetic and epigenetic alterations. The identification of prognostic biomarkers would help prevent or control metastatic progression. Expression analyses have been used to find such markers, but do not always validate in separate cohorts. Epigenetic marks, such as DNA methylation, are a potential source of more reliable and stable biomarkers. Importantly, the integration of both expression and epigenetic alterations is more likely to identify relevant biomarkers.

Results

We present a new analysis framework, using ESCC progression-associated gene regulatory network (GRN escc), to identify differentially methylated CpG site

SUBMITTER: Cheng CP 

PROVIDER: S-EPMC4609006 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature