Systematic analysis of gene properties influencing organ system phenotypes in mammalian perturbations.

ABSTRACT:

Motivation

Diseases and adverse drug reactions are frequently caused by disruptions in gene functionality. Gaining insight into the global system properties governing the relationships between genotype and phenotype is thus crucial to understand and interfere with perturbations in complex organisms such as diseases states.

Results

We present a systematic analysis of phenotypic information of 5047 perturbations of single genes in mice, 4766 human diseases and 1666 drugs that examines the relationships between different gene properties and the phenotypic impact at the organ system level in mammalian organisms. We observe that while single gene perturbations and alterations of nonessential, tissue-specific genes or those with low betweenness centrality in protein-protein intera

SUBMITTER: Vogt I 

PROVIDER: S-EPMC4609011 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature