E-Driver: a novel method to identify protein regions driving cancer.

ABSTRACT:

Motivation

Most approaches used to identify cancer driver genes focus, true to their name, on entire genes and assume that a gene, treated as one entity, has a specific role in cancer. This approach may be correct to describe effects of gene loss or changes in gene expression; however, mutations may have different effects, including their relevance to cancer, depending on which region of the gene they affect. Except for rare and well-known exceptions, there are not enough data for reliable statistics for individual positions, but an intermediate level of analysis, between an individual position and the entire gene, may give us better statistics than the former and better resolution than the latter approach.

Results

We have developed e-Driver, a method that exploits the inter

SUBMITTER: Porta-Pardo E 

PROVIDER: S-EPMC4609017 | biostudies-literature | 2014 Nov

REPOSITORIES: biostudies-literature