MicroRNA expression profiles of bovine milk exosomes in response to Staphylococcus aureus infection.

ABSTRACT:

Background

Milk exosomes are a rich source of microRNAs (miRNAs) that are protected from degradation. Ingestion of milk and subsequent absorption of miRNAs into recipient cells by endocytosis may play a role in the regulation of neonatal innate and adaptive immunity. In contrast, the miRNA content of milk exosomes may also be indicative of a lactating animal's health; whereby, the presence or absence of specific miRNAs could serve as biomarkers for early detection of bacterial infection that can lead to mastitis. In the present study, we therefore analyzed and compared miRNA expression profiles of milk exosomes from four Holstein cows obtained during mid-lactation prior to and after infection (48 h) of the mammary gland with Staphylococcus aureus.

Methods

Milk exosomes, puri

SUBMITTER: Sun J 

PROVIDER: S-EPMC4609085 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature