Characterization and annotation of Babesia orientalis apicoplast genome.

ABSTRACT:

Background

Babesia orientalis is an obligate intraerythrocytic protozoan parasite of the buffalo (Bubalus bubalis, Linnaeus, 1758) transmitted by the tick Rhipicephalus heamaphysaloides. It is the causative agent of water buffalo babesiosis, one of the most important pathogens of water buffalo in central and southern China. As a member of the phylum Apicomplexa, B. orientalis possesses a relatively independent and alga originated organelle the apicoplast. Apicoplasts in other apicomplexa parasites are involved in the biosynthesis of haem, fatty acids, iron-sulphur clusters and isoprenoids. Some of these metabolic pathways were shown to be essential for parasite survival, therefore can serve as potential drug targets.

Methods

30 pairs of primers were designed based on the ful

SUBMITTER: Huang Y 

PROVIDER: S-EPMC4609131 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature