In Silico Investigation for Evaluation of the Potential of the SclA Protein in Streptococcus pyogenes.

ABSTRACT: BACKGROUND:Streptococcus pyogenes is an important pathogen that is associated with a range of infections in humans, and causes common and severe invasive diseases. Currently, antimicrobial therapy is the first choice for the treatment of S. pyogenes; however, the emergence of antimicrobial resistance and side effects of antibacterial drugs is increasing. Consequently, there is an increased demand for novel drug targets and vaccine design. OBJECTIVES:To develop an effective vaccine against Streptococcus pyogenes (group A streptococcus) , we described a novel collagen-like surface protein of S. pyogenes which is important virulence factors. MATERIALS AND METHODS:In this study, we focused on the SclA protein of S. pyogenes and characterized it using bioinformatic tools to introduce it as a ca

SUBMITTER: Pourhajibagher M 

PROVIDER: S-EPMC4609172 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature