Inconsistencies in the hypophagic action of intracerebroventricular insulin in mice.

ABSTRACT: Insulin inhibits eating after its intracerebroventricular (ICV) administration in multiple species and under a variety of conditions. Nevertheless, the results across reports are inconsistent in that ICV insulin does not always reduce food intake. The reasons for this variability are largely unknown. Using mice as a model, we performed several crossover trials with insulin vs. vehicle when infused into the third cerebral ventricle (i3vt) to test the hypothesis that recent experience with the i3vt procedure contributes to the variability in the effect of ICV insulin on food intake. Using a cross-over design with two days between injections, we found that insulin (0.4 μU/mouse) significantly reduced food intake relative to vehicle in mice that received vehicle on the first and insulin on the

SUBMITTER: Mc Allister E 

PROVIDER: S-EPMC4609211 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature