MPnRAGE: A technique to simultaneously acquire hundreds of differently contrasted MPRAGE images with applications to quantitative T1 mapping.

ABSTRACT:

Purpose

To introduce a new technique called MPnRAGE, which produces hundreds of images with different T1 contrasts and a B1 corrected T1 map.

Theory and methods

An interleaved three-dimensional radial k-space trajectory with a sliding window reconstruction is used in conjunction with magnetization preparation pulses. This work modifies the SNAPSHOT-FLASH T1 fitting equations for radial imaging with view-sharing and develops a new rapid B1 correction procedure. MPnRAGE is demonstrated in phantoms and volunteers, including two volunteers with eight scans each and eight volunteers with two scans each. T1 values from MPnRAGE were compared with those from fast spin echo inversion recovery (FSE-IR) in phantoms and a healthy human brain at 3 Tesla (T).

Results

The T1 fit for

SUBMITTER: Kecskemeti S 

PROVIDER: S-EPMC4609219 | biostudies-literature | 2016 Mar

REPOSITORIES: biostudies-literature