Therapeutic combination of radiolabeled CLR1404 with external beam radiation in head and neck cancer model systems.

ABSTRACT:

Background and purpose

CLR1404 is a phospholipid ether that exhibits selective uptake and retention in malignant tissues. Radiolabeled CLR1404 enables tumor-specific positron-emission tomography (PET) imaging ((124)I) and targeted delivery of ionizing radiation ((131)I). Here we describe the first preclinical studies of this diapeutic molecule in head and neck cancer (HNC) models.

Material and methods

Tumor-selective distribution of (124)I-CLR1404 and therapeutic efficacy of (131)I-CLR1404 were tested in HNC cell lines and patient-derived xenograft tumor models. Monte Carlo dose calculations and (124)I-CLR1404 PET/CT imaging were used to examine (131)I-CLR1404 dosimetry in preclinical HNC tumor models.

Results

HNC tumor xenograft studies including patient-derived xeno

SUBMITTER: Morris ZS 

PROVIDER: S-EPMC4609259 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature