Resampling to Address the Winner's Curse in Genetic Association Analysis of Time to Event.

ABSTRACT: The "winner's curse" is a subtle and difficult problem in interpretation of genetic association, in which association estimates from large-scale gene detection studies are larger in magnitude than those from subsequent replication studies. This is practically important because use of a biased estimate from the original study will yield an underestimate of sample size requirements for replication, leaving the investigators with an underpowered study. Motivated by investigation of the genetics of type 1 diabetes complications in a longitudinal cohort of participants in the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications (DCCT/EDIC) Genetics Study, we apply a bootstrap resampling method in analysis of time to nephropathy under a Cox proportion

SUBMITTER: Poirier JG 

PROVIDER: S-EPMC4609263 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature