Prenatal exposure to persistent organochlorine pollutants is associated with high insulin levels in 5-year-old girls.

ABSTRACT:

Background

Several persistent organochlorine pollutants (POPs) possess endocrine disrupting abilities, thereby potentially leading to an increased risk of obesity and metabolic diseases, especially if the exposure occurs during prenatal life. We have previously found associations between prenatal POP exposures and increased BMI, waist circumference and change in BMI from 5 to 7 years of age, though only among girls with overweight mothers.

Objectives

In the same birth cohort, we investigated whether prenatal POP exposure was associated with serum concentrations of insulin and leptin among 5-year-old children, thus possibly mediating the association with overweight and obesity at 7 years of age.

Methods

The analyses were based on a prospective Faroese Birth Cohort (n=6

SUBMITTER: Tang-Peronard JL 

PROVIDER: S-EPMC4609268 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature