Concentration-dependent rheological properties of ECM hydrogel for intracerebral delivery to a stroke cavity.

ABSTRACT: Biomaterials composed of mammalian extracellular matrix (ECM) promote constructive tissue remodeling with minimal scar tissue formation in many anatomical sites. However, the optimal shape and form of ECM scaffold for each clinical application can vary markedly. ECM hydrogels have been shown to promote chemotaxis and differentiation of neuronal stem cells, but minimally invasive delivery of such scaffold materials to the central nervous system (CNS) would require an injectable form. These ECM materials can be manufactured to exist in fluid phase at room temperature, while forming hydrogels at body temperature in a concentration-dependent fashion. Implantation into the lesion cavity after a stroke could hence provide a means to support endogenous repair mechanisms. Herein, we characterize t

SUBMITTER: Massensini AR 

PROVIDER: S-EPMC4609617 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature