Evaluation of postpartum HIV superinfection and mother-to-child transmission.

ABSTRACT:

Objective

This study examined HIV superinfection in HIV-infected women postpartum, and its association with mother-to-child transmission (MTCT).

Design

Plasma samples were obtained from HIV-infected women who transmitted HIV to their infants after 6 weeks of age (transmitters, n = 91) and HIV-infected women who did not transmit HIV to their infants (nontransmitters, n = 91). These women were originally enrolled in a randomized trial for prevention of MTCT of HIV in Malawi (Post-Exposure Prophylaxis of Infants trial in Malawi).

Methods

Two HIV genomic regions (p24 and gp41) were analyzed by next-generation sequencing for HIV superinfection. HIV superinfection was established if the follow-up sample contained a new, phylogenetically distinct viral population. HIV superi

SUBMITTER: Redd AD 

PROVIDER: S-EPMC4609898 | biostudies-literature | 2015 Jul

REPOSITORIES: biostudies-literature