Synchronized age-related gene expression changes across multiple tissues in human and the link to complex diseases.

ABSTRACT: Aging is one of the most important biological processes and is a known risk factor for many age-related diseases in human. Studying age-related transcriptomic changes in tissues across the whole body can provide valuable information for a holistic understanding of this fundamental process. In this work, we catalogue age-related gene expression changes in nine tissues from nearly two hundred individuals collected by the Genotype-Tissue Expression (GTEx) project. In general, we find the aging gene expression signatures are very tissue specific. However, enrichment for some well-known aging components such as mitochondria biology is observed in many tissues. Different levels of cross-tissue synchronization of age-related gene expression changes are observed, and some essential tissues (e.g.,

SUBMITTER: Yang J 

PROVIDER: S-EPMC4609956 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature