The association between lower educational attainment and depression owing to shared genetic effects? Results in ~25,000 subjects.

ABSTRACT: An association between lower educational attainment (EA) and an increased risk for depression has been confirmed in various western countries. This study examines whether pleiotropic genetic effects contribute to this association. Therefore, data were analyzed from a total of 9662 major depressive disorder (MDD) cases and 14,949 controls (with no lifetime MDD diagnosis) from the Psychiatric Genomics Consortium with additional Dutch and Estonian data. The association of EA and MDD was assessed with logistic regression in 15,138 individuals indicating a significantly negative association in our sample with an odds ratio for MDD 0.78 (0.75-0.82) per standard deviation increase in EA. With data of 884,105 autosomal common single-nucleotide polymorphisms (SNPs), three methods were applied to te

SUBMITTER: Peyrot WJ 

PROVIDER: S-EPMC4610719 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature