Proteomic mechanisms of cardioprotection during mammalian hibernation in woodchucks, Marmota monax.

ABSTRACT: Mammalian hibernation is a unique strategy for winter survival in response to limited food supply and harsh climate, which includes resistance to cardiac arrhythmias. We previously found that hibernating woodchucks (Marmota monax) exhibit natural resistance to Ca2+ overload-related cardiac dysfunction and nitric oxide (NO)-dependent vasodilation, which maintains myocardial blood flow during hibernation. Since the cellular/molecular mechanisms mediating the protection are less clear, the goal of this study was to investigate changes in the heart proteome and reveal related signaling networks that are involved in establishing cardioprotection in woodchucks during hibernation. This was accomplished using isobaric tags for a relative and absolute quantification (iTRAQ) approach. The most signi

SUBMITTER: Li H 

PROVIDER: S-EPMC4610724 | biostudies-literature | 2013 Sep

REPOSITORIES: biostudies-literature