Drosophila E-cadherin is required for the maintenance of ring canals anchoring to mechanically withstand tissue growth.

ABSTRACT: Intercellular bridges called "ring canals" (RCs) resulting from incomplete cytokinesis play an essential role in intercellular communication in somatic and germinal tissues. During Drosophila oogenesis, RCs connect the maturing oocyte to nurse cells supporting its growth. Despite numerous genetic screens aimed at identifying genes involved in RC biogenesis and maturation, how RCs anchor to the plasma membrane (PM) throughout development remains unexplained. In this study, we report that the clathrin adaptor protein 1 (AP-1) complex, although dispensable for the biogenesis of RCs, is required for the maintenance of the anchorage of RCs to the PM to withstand the increased membrane tension associated with the exponential tissue growth at the onset of vitellogenesis. Here we unravel the mecha

SUBMITTER: Loyer N 

PROVIDER: S-EPMC4611665 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature