Mistranslation drives the evolution of robustness in TEM-1 β-lactamase.

ABSTRACT: How biological systems such as proteins achieve robustness to ubiquitous perturbations is a fundamental biological question. Such perturbations include errors that introduce phenotypic mutations into nascent proteins during the translation of mRNA. These errors are remarkably frequent. They are also costly, because they reduce protein stability and help create toxic misfolded proteins. Adaptive evolution might reduce these costs of protein mistranslation by two principal mechanisms. The first increases the accuracy of translation via synonymous "high fidelity" codons at especially sensitive sites. The second increases the robustness of proteins to phenotypic errors via amino acids that increase protein stability. To study how these mechanisms are exploited by populations evolving in the la

SUBMITTER: Bratulic S 

PROVIDER: S-EPMC4611672 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature