Type 3 innate lymphoid cells maintain intestinal epithelial stem cells after tissue damage.

ABSTRACT: Disruption of the intestinal epithelial barrier allows bacterial translocation and predisposes to destructive inflammation. To ensure proper barrier composition, crypt-residing stem cells continuously proliferate and replenish all intestinal epithelial cells within days. As a consequence of this high mitotic activity, mucosal surfaces are frequently targeted by anticancer therapies, leading to dose-limiting side effects. The cellular mechanisms that control tissue protection and mucosal healing in response to intestinal damage remain poorly understood. Type 3 innate lymphoid cells (ILC3s) are regulators of homeostasis and tissue responses to infection at mucosal surfaces. We now demonstrate that ILC3s are required for epithelial activation and proliferation in response to small intestinal

SUBMITTER: Aparicio-Domingo P 

PROVIDER: S-EPMC4612094 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature