Genomic profile predicts the efficacy of neoadjuvant chemotherapy for cervical cancer patients.

ABSTRACT:

Background

Neoadjuvant chemotherapy (NAC) using platinum and irinotecan (CPT-11) followed by radical excision has been shown to be a valid treatment for locally advanced squamous cervical cancer (SCC) patients. However, in NAC-resistant or NAC-toxic cases, surgical treatment or radiotherapy might be delayed and the prognosis may be adversely affected. Therefore, it is important to establish a method to predict the efficacy of NAC.

Methods

Gene expression microarrays of SCC tissue samples (n = 12) and UGT1A1 genotyping of blood samples (n = 23) were investigated in terms of their association with NAC sensitivity. Gene expression and drug sensitivity of SCC cell lines were analyzed for validation.

Results

Microarray analysis revealed that the glutathione metabolic pathw

SUBMITTER: Horikawa N 

PROVIDER: S-EPMC4612400 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature