Detection of clinically manifest and silent synovitis in the hands and wrists by fluorescence optical imaging.

ABSTRACT:

Objectives

The correct identification of synovitis is critical for achieving optimal therapy results. Fluorescence optical imaging (FOI) is a novel modality based on the use of an intravenous fluorophore, which enables fluorescent imaging of the hands and wrists with increased focal optical signal intensities in areas of high perfusion and/or capillary leakage. The study objective was to determine the diagnostic utility of FOI in detecting apparent and clinically non-apparent active synovitis.

Methods

Bilateral hand and wrist joints (n=872) of 26 patients with inflammatory arthritis assessed by standard clinical examination, musculoskeletal ultrasound (MSUS) and FOI were studied. Synovitis was defined as tender and swollen joints on clinical examination, presence of synovial

SUBMITTER: Kisten Y 

PROVIDER: S-EPMC4612680 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature