Association between MMP-12-82A/G polymorphism and cancer risk: a meta-analysis.

ABSTRACT:

Background

Numerous studies have focused on the association between MMP-12-82A>G polymorphism and cancer risk, but produced inconsistent results. Therefore, we performed a meta-analysis of case-control study to evaluate the association of MMP-12-82A>G polymorphism and cancer risk.

Methods

A systematic literature search was conducted among PubMed, Web of Science, Science Direct, China National Knowledge Infrastructure (CNKI) and Wangfang databases updated on May 1st, 2015. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were used to evaluate the strength of association between this polymorphism and cancer risk.

Results

A total of seventeen case-control studies with 7,450 cases and 7,348 controls were identified and analyzed. Overall, there was no statistica

SUBMITTER: Liu L 

PROVIDER: S-EPMC4612787 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature