Polymorphisms in the intercellular adhesion molecule 1 gene and cancer risk: a meta-analysis.

ABSTRACT:

Objectives

The correlation between intercellular adhesion molecule 1 (ICAM-1) common polymorphisms (rs5498 A>G and rs3093030 C>T) and cancer susceptibility has been explored in various ethnic groups and different cancer types; however, these investigations have yielded contradictory results. To address the relationship more precisely, we performed this meta-analysis.

Design and methods

EmBase, PubMed and China National Knowledge Infrastructure (CNKI) databases were searched by two authors independently for eligible publications before April 8, 2015. Random-effects or fixed-effects model was harnessed to calculate the pooled odds ratios (ORs) and 95% confidence intervals (CIs) when appropriate.

Results

The result suggested that the ICAM-1 rs5498 A>G polymorphism is not

SUBMITTER: Tang W 

PROVIDER: S-EPMC4612797 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature