The association between DVWA polymorphisms and osteoarthritis susceptibility: a genetic meta-analysis.

ABSTRACT: It has been reported that the double von Willebrandfactor domain A (DVWA) gene polymorphisms may be associated with osteoarthritis (OA) risk. However, some studies yielded conflicting results. Therefore, we conducted a comprehensive meta-analysis to identify the association of DVWA gene polymorphisms and the susceptibility to OA. We conducted a systematic search in PubMed, Embase (Ovid), China National Knowledge Internet (CNKI) and Wangfang databases up to May 15, 2015. Odds ratio (OR) and 95% confidence interval (CI) were used to pool the effect size. Statistical analyses were performed with STATA 11.0 software. In total, 11 studies from five articles with 13,579 subjectswere included in this meta-analysis. The overall results indicated that there was a significant association between DVW

SUBMITTER: Wang D 

PROVIDER: S-EPMC4612852 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature