Leptin receptor gene polymorphisms and risk of hypertension: a meta-analysis.

ABSTRACT:

Objective

To assess the relationship between the polymorphisms of leptin receptor gene and hypertension.

Methods

Meta analysis was conducted by using RevMan 5.3. Relevant literatures were retrieved by searching PubMed using the keywords "Hypertension", "Leptin Receptor", "OB Receptor", "LEPR Protein".

Results

Fifteen studies with a total of 5955 patients with hypertension and 3830 healthy controls were included in this meta-analysis. The results showed that Gln223Arg gene polymorphism was significantly higher in hypertension patients than in control (OR=1.36, 95% CI=1.23-1.51, P<0.00001). However, no statistically significant difference was found in Lys109Arg polymorphism between hypertension patients and control (OR=0.99, 95% CI=0.85-1.16, P=0.91).

Conclusion

SUBMITTER: Lian Y 

PROVIDER: S-EPMC4613096 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature