CD8 Memory Cells Develop Unique DNA Repair Mechanisms Favoring Productive Division.

ABSTRACT: Immune responses are efficient because the rare antigen-specific naïve cells are able to proliferate extensively and accumulate upon antigen stimulation. Moreover, differentiation into memory cells actually increases T cell accumulation, indicating improved productive division in secondary immune responses. These properties raise an important paradox: how T cells may survive the DNA lesions necessarily induced during their extensive division without undergoing transformation. We here present the first data addressing the DNA damage responses (DDRs) of CD8 T cells in vivo during exponential expansion in primary and secondary responses in mice. We show that during exponential division CD8 T cells engage unique DDRs, which are not present in other exponentially dividing cells, in T lymphocyte

SUBMITTER: Galgano A 

PROVIDER: S-EPMC4613136 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature