Identification of Conserved and Novel MicroRNAs during Tail Regeneration in the Mexican Axolotl.

ABSTRACT: The Mexican axolotl salamander (Ambystoma mexicanum) is one member of a select group of vertebrate animals that have retained the amazing ability to regenerate multiple body parts. In addition to being an important model system for regeneration, the axolotl has also contributed extensively to studies of basic development. While many genes known to play key roles during development have now been implicated in various forms of regeneration, much of the regulatory apparatus controlling the underlying molecular circuitry remains unknown. In recent years, microRNAs have been identified as key regulators of gene expression during development, in many diseases and also, increasingly, in regeneration. Here, we have used deep sequencing combined with qRT-PCR to undertake a comprehensive identificat

SUBMITTER: Gearhart MD 

PROVIDER: S-EPMC4613296 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature