Budget impact analysis of CYP2C19-guided voriconazole prophylaxis in AML.

ABSTRACT:

Objectives

The objective of this study was to determine the economic impact of proactive, CYP2C19 genotype-guided voriconazole prophylaxis in AML.

Methods

An Excel-based model was created to project the cost of treating a simulated cohort of severely neutropenic AML patients undergoing antifungal prophylaxis. The model compares (i) standard prophylactic dosing with voriconazole and (ii) CYP2C19 genotyping of all AML patients to guide voriconazole dosing and prescribing.

Results

Based on the model, genotype-guided dosing of voriconazole conservatively spares 2.3 patients per year from invasive fungal infections. Implementing proactive genotyping of all AML patients in a simulated 100 patient cohort is expected to save a total of $41467 or $415 per patient.

Conclusio

SUBMITTER: Mason NT 

PROVIDER: S-EPMC4613741 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature