Disconnection of network hubs and cognitive impairment after traumatic brain injury.

ABSTRACT: Traumatic brain injury affects brain connectivity by producing traumatic axonal injury. This disrupts the function of large-scale networks that support cognition. The best way to describe this relationship is unclear, but one elegant approach is to view networks as graphs. Brain regions become nodes in the graph, and white matter tracts the connections. The overall effect of an injury can then be estimated by calculating graph metrics of network structure and function. Here we test which graph metrics best predict the presence of traumatic axonal injury, as well as which are most highly associated with cognitive impairment. A comprehensive range of graph metrics was calculated from structural connectivity measures for 52 patients with traumatic brain injury, 21 of whom had microbleed evide

SUBMITTER: Fagerholm ED 

PROVIDER: S-EPMC4614120 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature