The Effect of Oral Polio Vaccine at Birth on Infant Mortality: A Randomized Trial.

ABSTRACT:

Background

Routine vaccines may have nonspecific effects on mortality. An observational study found that OPV given at birth (OPV0) was associated with increased male infant mortality. We investigated the effect of OPV0 on infant mortality in a randomized trial in Guinea-Bissau.

Methods

A total of 7012 healthy normal-birth-weight neonates were randomized to BCG only (intervention group) or OPV0 with BCG (usual practice). All children were to receive OPV with pentavalent vaccine (diphtheria, tetanus, pertussis, Haemophilus influenzae type b, and hepatitis B) at 6, 10, and 14 weeks of age. Seven national OPV campaigns were also conducted during the trial period. Children were followed to age 12 months. We used Cox regression to calculate hazard ratios (HRs) for mortality.

Re

SUBMITTER: Lund N 

PROVIDER: S-EPMC4614411 | biostudies-literature | 2015 Nov

REPOSITORIES: biostudies-literature