Mapping high-growth phenotypes in the flux space of microbial metabolism.

ABSTRACT: Experimental and empirical observations on cell metabolism cannot be understood as a whole without their integration into a consistent systematic framework. However, the characterization of metabolic flux phenotypes is typically reduced to the study of a single optimal state, such as maximum biomass yield that is by far the most common assumption. Here, we confront optimal growth solutions to the whole set of feasible flux phenotypes (FFPs), which provides a benchmark to assess the likelihood of optimal and high-growth states and their agreement with experimental results. In addition, FFP maps are able to uncover metabolic behaviours, such as aerobic fermentation accompanying exponential growth on sugars at nutrient excess conditions, that are unreachable using standard models based on opt

SUBMITTER: Guell O 

PROVIDER: S-EPMC4614465 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature