DyNAMiC Workbench: an integrated development environment for dynamic DNA nanotechnology.

ABSTRACT: Dynamic DNA nanotechnology provides a promising avenue for implementing sophisticated assembly processes, mechanical behaviours, sensing and computation at the nanoscale. However, design of these systems is complex and error-prone, because the need to control the kinetic pathway of a system greatly increases the number of design constraints and possible failure modes for the system. Previous tools have automated some parts of the design workflow, but an integrated solution is lacking. Here, we present software implementing a three 'tier' design process: a high-level visual programming language is used to describe systems, a molecular compiler builds a DNA implementation and nucleotide sequences are generated and optimized. Additionally, our software includes tools for analysing and 'debugg

SUBMITTER: Grun C 

PROVIDER: S-EPMC4614494 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature