A self-regulating biomolecular comparator for processing oscillatory signals.

ABSTRACT: While many cellular processes are driven by biomolecular oscillators, precise control of a downstream on/off process by a biochemical oscillator signal can be difficult: over an oscillator's period, its output signal varies continuously between its amplitude limits and spends a significant fraction of the time at intermediate values between these limits. Further, the oscillator's output is often noisy, with particularly large variations in the amplitude. In electronic systems, an oscillating signal is generally processed by a downstream device such as a comparator that converts a potentially noisy oscillatory input into a square wave output that is predominantly in one of two well-defined on and off states. The comparator's output then controls downstream processes. We describe a method fo

SUBMITTER: Agrawal DK 

PROVIDER: S-EPMC4614497 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature