Blood flow through the embryonic heart outflow tract during cardiac looping in HH13-HH18 chicken embryos.

ABSTRACT: Blood flow is inherently linked to embryonic cardiac development, as haemodynamic forces exerted by flow stimulate mechanotransduction mechanisms that modulate cardiac growth and remodelling. This study evaluated blood flow in the embryonic heart outflow tract (OFT) during normal development at each stage between HH13 and HH18 in chicken embryos, in order to characterize changes in haemodynamic conditions during critical cardiac looping transformations. Two-dimensional optical coherence tomography was used to simultaneously acquire both structural and Doppler flow images, in order to extract blood flow velocity and structural information and estimate haemodynamic measures. From HH13 to HH18, peak blood flow rate increased by 2.4-fold and stroke volume increased by 2.1-fold. Wall shear rate

SUBMITTER: Midgett M 

PROVIDER: S-EPMC4614502 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature