Mitonuclear linkage disequilibrium in human populations.

ABSTRACT: There is extensive evidence from model systems that disrupting associations between co-adapted mitochondrial and nuclear genotypes can lead to deleterious and even lethal consequences. While it is tempting to extrapolate from these observations and make inferences about the human-health effects of altering mitonuclear associations, the importance of such associations may vary greatly among species, depending on population genetics, demographic history and other factors. Remarkably, despite the extensive study of human population genetics, the statistical associations between nuclear and mitochondrial alleles remain largely uninvestigated. We analysed published population genomic data to test for signatures of historical selection to maintain mitonuclear associations, particularly those inv

SUBMITTER: Sloan DB 

PROVIDER: S-EPMC4614761 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature