Next generation sequencing demonstrates association between tumor suppressor gene aberrations and poor outcome in patients with cancer.

ABSTRACT: Next generation sequencing is transforming patient care by allowing physicians to customize and match treatment to their patients' tumor alterations. Our goal was to study the association between key molecular alterations and outcome parameters. We evaluated the characteristics and outcomes (overall survival (OS), time to metastasis/recurrence, and best progression-free survival (PFS)) of 392 patients for whom next generation sequencing (182 or 236 genes) had been performed. The Kaplan-Meier method and Cox regression models were used for our analysis, and results were subjected to internal validation using a resampling method (bootstrap analysis). In a multivariable analysis (Cox regression model), the parameters that were statistically associated with a poorer overall survival were the pr

SUBMITTER: Schwaederle M 

PROVIDER: S-EPMC4614790 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature