A functional module-based exploration between inflammation and cancer in esophagus.

ABSTRACT: Inflammation contributing to the underlying progression of diverse human cancers has been generally appreciated, however, explorations into the molecular links between inflammation and cancer in esophagus are still at its early stage. In our study, we presented a functional module-based approach, in combination with multiple data resource (gene expression, protein-protein interactions (PPI), transcriptional and post-transcriptional regulations) to decipher the underlying links. Via mapping differentially expressed disease genes, functional disease modules were identified. As indicated, those common genes and interactions tended to play important roles in linking inflammation and cancer. Based on crosstalk analysis, we demonstrated that, although most disease genes were not shared by both k

SUBMITTER: Liu N 

PROVIDER: S-EPMC4614801 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature