Biconnectivity of the cellular metabolism: A cross-species study and its implication for human diseases.

ABSTRACT: The maintenance of stability during perturbations is essential for living organisms, and cellular networks organize multiple pathways to enable elements to remain connected and communicate, even when some pathways are broken. Here, we evaluated the biconnectivity of the metabolic networks of 506 species in terms of the clustering coefficients and the largest biconnected components (LBCs), wherein a biconnected component (BC) indicates a set of nodes in which every pair is connected by more than one path. Via comparison with the rewired networks, we illustrated how biconnectivity in cellular metabolism is achieved on small and large scales. Defining the biconnectivity of individual metabolic compounds by counting the number of species in which the compound belonged to the LBC, we demonstrat

SUBMITTER: Kim P 

PROVIDER: S-EPMC4614848 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature