Positive correlation between ADAR expression and its targets suggests a complex regulation mediated by RNA editing in the human brain.

ABSTRACT: A-to-I RNA editing by adenosine deaminases acting on RNA is a post-transcriptional modification that is crucial for normal life and development in vertebrates. RNA editing has been shown to be very abundant in the human transcriptome, specifically at the primate-specific Alu elements. The functional role of this wide-spread effect is still not clear; it is believed that editing of transcripts is a mechanism for their down-regulation via processes such as nuclear retention or RNA degradation. Here we combine 2 neural gene expression datasets with genome-level editing information to examine the relation between the expression of ADAR genes with the expression of their target genes. Specifically, we computed the spatial correlation across structures of post-mortem human brains between ADAR an

SUBMITTER: Liscovitch N 

PROVIDER: S-EPMC4615195 | biostudies-literature | 2014

REPOSITORIES: biostudies-literature