MicroRNA-20a is essential for normal embryogenesis by targeting vsx1 mRNA in fish.

ABSTRACT: MicroRNAs are major post-transcriptional regulators of gene expression and have essential roles in diverse developmental processes. In vertebrates, some regulatory genes play different roles at different developmental stages. These genes are initially transcribed in a wide embryonic region but restricted within distinct cell types at subsequent stages during development. Therefore, post-transcriptional regulation is required for the transition from one developmental stage to the next and the establishment of different cell identities. However, the regulation of many multiple functional genes at post-transcription level during development remains unknown. Here we show that miR-20a can target the mRNA of vsx1, a multiple functional gene, at the 3'-UTR and inhibit protein expression in both g

SUBMITTER: Sun L 

PROVIDER: S-EPMC4615322 | biostudies-literature | 2015

REPOSITORIES: biostudies-literature