APOL1 Genotype and Glomerular and Tubular Kidney Injury in Women With HIV.

ABSTRACT:

Background

APOL1 genotype is associated with advanced kidney disease in African Americans, but the pathogenic mechanisms are unclear. Here, associations of APOL1 genotype with urine biomarkers of glomerular and tubular injury and kidney function decline were evaluated.

Study design

Observational study.

Setting & participants

431 human immunodeficiency virus (HIV)-infected African American women enrolled in Women's Interagency HIV Study (WIHS).

Predictor

APOL1 genotype.

Outcomes

Albumin-creatinine ratio (ACR), 4 tubular injury biomarkers (interleukin 18 [IL-18], kidney injury molecule 1 [KIM-1], neutrophil gelatinase-associated lipocalin [NGAL], and α1-microglobulin [A1M]), and kidney function estimated using the CKD-EPI cystatin C equation.

Measuremen

SUBMITTER: Jotwani V 

PROVIDER: S-EPMC4615696 | biostudies-literature | 2015 Jun

REPOSITORIES: biostudies-literature