Association of genetic variants in and promoter hypermethylation of CDH1 with gastric cancer: a meta-analysis.

ABSTRACT: Gastric cancer (GC) is a common cause of cancer-related death. The etiology and pathogenesis of GC remain unclear, with genetic and epigenetic factors playing an important role. Previous studies investigated the association of GC with many genetic variants in and promoter hypermethylation of E-cadherin gene (CDH1), with conflicting results reported.To clarify this inconsistency, we conducted updated meta-analyses to assess the association of genetic variants in and the promoter hypermethylation of CDH1 with GC, including C-160A (rs16260) and other less-studied genetic variants,Data sources were PubMed, Cochrane Library, Google Scholar, Web of Knowledge, and HuGE, a navigator for human genome epidemiology.Study eligibility criteria and participant details are as follows: studies were conduc

SUBMITTER: Jing H 

PROVIDER: S-EPMC4616322 | biostudies-literature | 2014 Oct

REPOSITORIES: biostudies-literature