Impact of ESR1 Gene Polymorphisms on Migraine Susceptibility: A Meta-Analysis.

ABSTRACT: An increasing number of studies have explored genetic associations between the functionally important polymorphisms in estrogen receptor 1 (ESR1) gene and migraine susceptibility. The previously reported associations have nevertheless been inconsistent.The present work incorporating the published data derived from 8 publications was performed to assess the impact of these polymorphisms on incident migraine. Strength of the genetic risk was estimated by means of an odds ratio along with the 95% confidence interval (OR and 95% CI).From the results, we found individuals who harbored the 325-GG genotype, compared with those harboring the CC genotype or CG and CC combined genotypes, had almost 50% greater risk of migraine. The same genetic models showed notable associations in subgroups of Cauc

SUBMITTER: Li L 

PROVIDER: S-EPMC4616512 | biostudies-literature | 2015 Sep

REPOSITORIES: biostudies-literature