Eating behavior in frontotemporal dementia: Peripheral hormones vs hypothalamic pathology.

ABSTRACT:

Objective

To contrast the relationships of hormonal eating peptides and hypothalamic volumes to eating behavior and metabolic changes (body mass index [BMI]) in behavioral variant frontotemporal dementia (bvFTD) and semantic variant primary progressive aphasia (svPPA).

Methods

Seventy-five patients with dementia (19 bvFTD, 26 svPPA, and 30 Alzheimer disease dementia) and 23 controls underwent fasting blood analyses of leptin, ghrelin, cholecystokinin, peptide tyrosine tyrosine (PYY), and agouti-related peptide (AgRP) levels. On brain MRI anterior, posterior, and total hypothalamic volumes were measured. Relationships between endocrine measures, hypothalamic volumes, eating behaviors, and BMI were investigated.

Results

Levels of AgRP were higher in patients with bvFTD

SUBMITTER: Ahmed RM 

PROVIDER: S-EPMC4617167 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature