Longitudinal study of normal cognition in Parkinson disease.

ABSTRACT:

Objective

To report the rates and predictors of progression from normal cognition to either mild cognitive impairment (MCI) or dementia using standardized neuropsychological methods.

Methods

A prospective cohort of patients diagnosed with Parkinson disease (PD) and baseline normal cognition was assessed for cognitive decline, performance, and function for a minimum of 2 years, and up to 6. A panel of movement disorders experts classified patients as having normal cognition, MCI, or dementia, with 55/68 (80.9%) of eligible patients seen at year 6. Kaplan-Meier curves and Cox proportional hazard models were used to examine cognitive decline and its predictors.

Results

We enrolled 141 patients, who averaged 68.8 years of age, 63% men, who had PD on average for 5 years. T

SUBMITTER: Pigott K 

PROVIDER: S-EPMC4617168 | biostudies-literature | 2015 Oct

REPOSITORIES: biostudies-literature