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Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.

ABSTRACT: In this report, we reasoned that non-covalent modification of amyloid beta (A?) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label A? plaques and CAAs in AD mice.

SUBMITTER: Tian Y 

PROVIDER: S-EPMC4617529 | biostudies-literature | 2014 Dec

REPOSITORIES: biostudies-literature

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Crown ethers attenuate aggregation of amyloid beta of Alzheimer's disease.

Tian Yanli Y   Zhang Xueli X   Li Yuyan Y   Shoup Timothy M TM   Teng Xin X   Elmaleh David R DR   Moore Anna A   Ran Chongzhao C  

Chemical communications (Cambridge, England) 20141105 99

In this report, we reasoned that non-covalent modification of amyloid beta (Aβ) by crown ethers could inhibit its aggregation. We demonstrated that PiB-C, a conjugate PiB and crown ether, could significantly reduce the aggregation in vitro. Additionally, two-photon imaging showed that PiB-C could efficiently label Aβ plaques and CAAs in AD mice. ...[more]

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